To understand neural coding of behavior and the co-activity between neurons in distinct brain regions we implant a 32-tetrode device allowing us to record from multiple individual neurons from brain regions of interest while animals perform memory-guided goal-directed behavioral tasks.
Tetrode recording techniques are based on multiple 4-channel probes whose distinct proximity to the population of neurons permits the allocation of different action potential waveforms to distinct neurons, through a process of triangulation.
Tetrode recording techniques are based on multiple 4-channel probes whose distinct proximity to the population of neurons permits the allocation of different action potential waveforms to distinct neurons, through a process of triangulation.
Appropriate filtering and thresholding of voltage traces allow us to then monitor the activity of single neurons and populations thereof, during distinct behavioral states